Intravenous self-administration studies with l-deprenyl (selegiline) in monkeys*
نویسندگان
چکیده
منابع مشابه
Aminergic influences on intravenous cocaine self-administration by Rhesus monkeys.
WILSON, M. C. AND C. R. SCHUSTER. Aminergic influences on intravenous cocaine self-administration by rhesus monkeys. PHARMAC. BIOCHEM. BEHAV. 2(5) 563-571, 1974. Earlier observations have demonstrated that when allowed limited daily access to cocaine, monkeys self-administer approximately the same amount of cocaine dally. Treatment with neuroleptic agents increases the frequency of this behavio...
متن کاملCholinergic influence on intravenous cocaine self-administration by rhesus monkeys.
WILSON, M. C. AND C. R. SCHUSTER. 67rolhlergic influence on intravenous cocaine self-administration by rhesus monkeys. PHARMAC. BIOCHEM. BEIIAV. 1(6) 643-649, 1973.-The effects of intramuscular administration of atropine, methylatropine and physostigmine on intravenous cocaine self-administration in the rhesus monkey were ascertained. Atropine (0.5-2.0 mg/kg) increased cocaine intake, whereas m...
متن کاملStudies on anticonvulsant actions of L-deprenyl.
L-Deprenyl (Selegeline) introduced for use in parkinson's disease, is implicated to show beneficial effects in epilepsy, alzheimer's disease, cognition, depression and other age related neurological diseases. In this study, we investigated the CNS effects of L-deprenyl with special reference to epilepsy, anxiety and cognition and memory in mice. L-deprenyl (10, 20 and 40 mg/kg) showed a signifi...
متن کاملThe effect of L-arginine and L-NAME on intravenous self-administration of morphine in rats
The involvement of nitric oxide (NO) in the reinforcing properties of opiate reward was studied by examining the effect of a NO precursor (L-arginine) and a NO synthase inhibitor (L-NAME) on the rate of intravenous self-administration of morphine. This experiment was investigated in male albino Sprague Dawley rats (300 ± 50 g). At doses of 5 and 10 mg/kg (i.p.), L-arginine decreased morphine ...
متن کاملMethods for Intravenous Self Administration in a Mouse Model
Animal models have been developed to study the reinforcing effects of drugs, including the intravenous self-administration (IVSA) paradigm. The advantages of using an IVSA paradigm to study the reinforcing properties of drugs of abuse such as cocaine include the fact that the drug is self-administered instead of experimenter-administered, the schedule of reinforcement can be altered, and accura...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Pharmacology and Therapeutics
سال: 1994
ISSN: 0009-9236,1532-6535
DOI: 10.1038/clpt.1994.208